Cyclic conjugated enediynes

Details Cyclic conjugated enediynes Cyclic conjugated enediynes

1991-12-09

1993-08-24

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

564152, 4353201, 435964, 436 64, 436128, 436548, 536 551, 536 552, 536 45, 536 50, C07C23300

Patent

active

052391183

ABSTRACT:
The synthesis of stable, ten-membered, cyclic conjugated enediynes is described. Said compounds were successfully employed to cleave double-stranded DNA spontaneously at ambient temperatures.

REFERENCES:
Anon., Synform, 8(2), 90-112, 1990.
Singh, R. et al., Tetrahedron Lett., 31(2) 185-8, 1990.
Nicolaou, K. C. et al., J. Am. Chem. Soc. 110(21) 7247-48, 1988.

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