Cyclic compounds, their prudiction and use

Details Cyclic compounds, their prudiction and use Cyclic compounds, their prudiction and use

1996-09-23

1998-06-23

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514220, 540460, 540461, 540497, A61K 3133, A61K 3155, C07D24500, C07D48700

Patent

active

057705909

ABSTRACT:
Novel compounds of the following general formula or salts thereof. ##STR1## wherein Ring M is a heterocyclic ring having --N.dbd.C<, --CO--N< or --CS--N< as the partial structure --X . . . Y<; R.sup.a and R.sup.b are bonded to each other to form Ring A, or they are the same or different and represent, independently, a hydrogen atom or a substituent on the Ring M; Ring A and Ring B represent, independently, an optionally substituted homocyclic or heterocyclic ring, and at least one of them is optionally substituted heterocyclic ring; Rng C is optionally substituted homocyclic or heterocyclic ring; Rng Z is an optionally substituted ring; and n represents an integer of from 1 to 6, or a salt thereof, which has anexcellent tachykinin receptor antagonistic effect, and their production, and pharmaceutical compositions.

REFERENCES:
patent: 3987047 (1976-10-01), Gries et al.
patent: 5070086 (1991-12-01), Friary
Series, pp. 609-610, Oct. 1973.
Snyder et al., Preparation of Compounds in the New 1-Benzylidene-2,3-Dioxopyrrolidines., pp. 603-607, May-Jun. 1982.
Sato et al. Synthetic Studies on Cardiovascular Agents, Chemical Abstracts, vol. 89, No. 7, Aug. 1978, p. 570, Zasshi, vol. 98, No. 4, 1978, pp. 448-465.

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