Cyclic compounds, their production and use

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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514302, 540455, 540488, 540490, A61K 3155, A61K 31553, A61K 31554, C07D26722, C07D26702

Patent

active

061470716

ABSTRACT:
Novel compounds of the following general formula or salts thereof. ##STR1## wherein Ring M is a heterocyclic ring having --N.dbd.CC<, --CO--N< or --CS--N< as the partial structure --X . . . . . Y<; R.sup.a and R.sup.b are bonded to each other to form Ring A, or they are the same or different and represent, independently, a hydrogen atom or a substituent on the Ring M; Ring A and Ring B represent, independently, an optionally substituted homocyclic or heterocyclic ring, and at least one of them is optionally substituted heterocyclic ring; Ring C is optionally substituted homocyclic or heterocyclic ring; Ring Z is an optionally substituted ring; and n represents an integer of from 1 to 6, or a salt thereof, which has an excellent tachykinin receptor antagonistic effect, and their production, and pharmaceutical compositions.

REFERENCES:
patent: 3987047 (1976-10-01), Griss et al.
patent: 4746657 (1988-05-01), Cale, Jr.
R. Madhav, A New Synthesis of Compounds in the 5H-Pyrrolo-[3,4-b] Pyridine Series, pp. 609-610, Oct. 1973.
Snyder et al., Preparation of Compounds in the New Dipyrrolo[3,4-b:3',4'-e-]-Pyridine Series From 1-Benzylidene-2,3-Dioxopyrrolidines., pp. 603-607, May-Jun. 1982.
Sato et al. Synthetic Studies on Cardiovascular Agents, Chemical Abstracts, vol. 89, No. 7, Aug. 1978, p. 570, Zasshi, vol. 98, No. 4, 1978, pp. 448-65.

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