Cyclic compound and PPAR agonist

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C548S146000, C548S200000, C548S215000, C548S247000, C546S184000, C546S268100, C546S281700, C546S284700, C544S224000, C544S336000, C544S358000, C549S013000, C549S020000, C549S429000, C549S484000, C514S365000, C514S374000

Reexamination Certificate

active

07371777

ABSTRACT:
The present invention provides a novel compound having an excellent PPAR agonist action. More specifically, it provides a compound represented by the following formula, a salt thereof, an ester thereof or a hydrate of them.Wherein a, b and c are the same as or different from one another and each represents 0 to 4; R1to R6are the same as or different from one another and each represents a hydrogen atom, a hydroxyl group, a cyano group, a halogen atom, etc.;A1and A2are the same as or different from each other and each represents a single bond, an oxygen atom, etc.;L, M and T each represent a single bond, an alkylene group having one to six carbon atoms, etc.;W represents a carboxyl group;the partial structure represented by the formula:represents a single bond or a double bond;X represents a single bond, an oxygen atom, —NRx1CQ1O—, etc.;Y represents Y1—Y2— (wherein Y1represents a 5 to 14-membered aromatic ring having one to four substituents, etc.; and Y2represents a single bond or a 5 to 14-membered aromatic ring); andthe ring Z represents a 5 to 14-membered aromatic ring which have one to four substituents selected form the above-mentioned Group A, may have one or more hetero atoms and may be partially saturated.

REFERENCES:
patent: 6506797 (2003-01-01), Nomura et al.
patent: 6884821 (2005-04-01), Shinoda et al.
patent: 7244861 (2007-07-01), Matsuura et al.
patent: 7253178 (2007-08-01), Harada et al.
patent: 2004/0102634 (2004-05-01), Matsuura et al.
patent: 2004/0116708 (2004-06-01), Harada et al.
patent: 2004/0138271 (2004-07-01), Matsuura et al.
patent: 2004/0214888 (2004-10-01), Matsuura et al.
patent: 2005/0014833 (2005-01-01), Clark et al.
patent: 3026924 (1982-02-01), None
patent: 0028063 (1981-05-01), None
patent: 0219308 (1987-04-01), None
patent: 0 543 662 (1993-05-01), None
patent: 1026149 (2000-08-01), None
patent: 57-064639 (1982-04-01), None
patent: 9-48771 (1997-02-01), None
patent: 11-152269 (1999-06-01), None
patent: 2001-55367 (2001-02-01), None
patent: 2001-261612 (2001-09-01), None
patent: WO-89/03819 (1989-05-01), None
patent: WO-90/06920 (1990-06-01), None
patent: WO-94/01420 (1994-01-01), None
patent: WO-94/13650 (1994-06-01), None
patent: WO-95/03288 (1995-02-01), None
patent: WO 99/04815 (1999-02-01), None
patent: WO 99/16758 (1999-04-01), None
patent: WO 99/18066 (1999-04-01), None
patent: WO 99/20275 (1999-04-01), None
patent: WO-99/65897 (1999-12-01), None
patent: WO 00/04011 (2000-01-01), None
patent: WO-00/64876 (2000-11-01), None
patent: WO 00/64888 (2000-11-01), None
patent: WO 00/75103 (2000-12-01), None
patent: WO-01/55086 (2001-02-01), None
patent: WO-01/21578 (2001-03-01), None
patent: WO-01/25181 (2001-04-01), None
patent: WO-01/38325 (2001-05-01), None
patent: WO-01/55085 (2001-08-01), None
patent: WO-01/92201 (2001-12-01), None
patent: WO-02/100812 (2002-01-01), None
patent: WO-02/079162 (2002-10-01), None
patent: WO-02/080899 (2002-10-01), None
patent: WO-02/081428 (2002-10-01), None
patent: WO 02/083616 (2002-10-01), None
patent: WO 02/098840 (2002-12-01), None
patent: WO-03/016265 (2003-02-01), None
Jurgen M. Lehmann et al.; The Journal of Biological Chemistry; vol. 270, No. 22, Issue of June 2, pp. 12953-12956, 1995.
Timothy M. Willson et al.; Journal of Medicinal Chemistry; vol. 43, No. 4, Feb. 24, 2000, pp. 527-550.
Philip M. Barger et al.; Trends Cardiovasc. Med., vol. 10, No. 6, 2000, pp. 238-245.
Bernard Hulin et al.; Current Pharmaceutical Design, 2, No. 1, pp. 85-102, 1996.
D.R. Buckle et al.; Bioorganic & Medicinal Chemistry Letters, vol. 6, No. 17, pp. 2121-2126, 1996.
Clarie Bastie et al.; The Journal of Biological Chemistry, vol. 274, No. 31, Issue of July 30, pp. 21920-21925, 1999.
Miyachi et al., Bioorganic & Medicinal Chemistry Letters, vol. 12, 2002, pp. 77-80.
“Nuovi Coloranti Per Miste Poliestere/Cotone” Tinctoria, 1996, vol. 93, No. 5, pp. 34-39.
Gibson et al., European Journal of Medicinal Chemistry, vol. 32, No. 10, 1997, pp. 823-831.
Young et al., The Journal of Pharmacology and Experimental Therapeutics, vol. 284, No. 2, 1997, pp. 751-759.
Haigh et al., Bioorganic & Medicinal Chemistry, vol. 7, No. 5, 1999, pp. 821-830.
Lavoie et al., Bioorganic & Medicinal Chemistry Letters, vol. 11, No. 21, pp. 2847-2850.
Li et al., Hcaplus 2006:256663, “Peroxisome proliferators-activated receptors: how their effects on macrophages can lead to the development of a new drug therapy against atherosclerosis”, Annual Review of Pharmacology and Toxicology, 2006.
Kurtz, Hcaplus 2006:551484, “New treatment strategies for patients with hypertension and insulin resistance”, American Journal of Medicine, 2006.

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