Cyclic cell adhesion modulation compounds

Details Cyclic cell adhesion modulation compounds Cyclic cell adhesion modulation compounds

1990-07-09

1993-03-09

Lee, Lester L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 9, 514 15, 514 16, 514 17, 530317, 530328, 530329, 530330, A61K 3702, C07K 500, C07K 700, C07K 1500

Patent

active

051927462

ABSTRACT:
Cyclized integrin receptor antagonist compounds useful in modulating cell adhesion to integrin receptors, including adhesion related to fibronectin and/or fibronectin receptors, are disclosed. Methods for synthesizing, testing, formulating, and using the compounds as therapeutic agents are also disclosed.

REFERENCES:
patent: 4792525 (1988-12-01), Ruoslahti et al.
Lam et al., J. Bio. Chem, vol. 262, No. 3, 1987, pp. 947-950.
Pierschbacher et al., J. Biol. Chem., vol. 262, 1987, pp. 17294-17298.

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