Cyclic bradykinin antagonist peptides

Details Cyclic bradykinin antagonist peptides Cyclic bradykinin antagonist peptides

1994-07-25

1996-08-06

Parr, Margaret

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Bradykinin; kallidin; related peptides

530317, 930270, C07K 718, C07K 752, A61K 3812

Patent

active

055434967

ABSTRACT:
Cyclic compounds based on a modified bradykinin sequence are potent bradykinin receptor antagonists. Amino acid substitutions are made at postions 2 and 5 or 6 to facilitate the cyclization of the peptide through covalent bonding of the amino acid side chains.
The analogs produced are useful in treating conditions and diseases of a mammal and human in which an excess of bradykinin or related kinins are produced or injected such as by insect bites.

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