Cyclic Antiplatelet peptides with pseudo-bond

Details Cyclic Antiplatelet peptides with pseudo-bond Cyclic Antiplatelet peptides with pseudo-bond

1997-04-09

2000-08-22

MacMillan, Keith D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 9, 514 2, 530317, 530330, A61K 3812, C07K 512

Patent

active

061072753

ABSTRACT:
The present invention relates to cyclic peptide analogs containing a pseudo-bond, useful as platelet aggregation inhibitors. An example of a compound of this invention includes Cyclo[Ala.PSI.[CH.sub.2 NH]-Arg-Gly-Asp-.delta.-Glu](NHBn).cndot.CF.sub.3 CO.sub.2 H. These compounds inhibit the binding of fibrinogen to the platelet GPIIb-IIIa integrin receptor which inhibits platelet aggregation and therefore these compounds act as potent antithrombotics.

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