Cyclic analogs of PTH and PTHrP

Details Cyclic analogs of PTH and PTHrP Cyclic analogs of PTH and PTHrP

1995-06-07

1998-02-10

Tsang, Cecilia J.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Cyclic peptides

A61K 3800, C07K 500, C07K 700, C07K 1600

Patent

active

057170622

ABSTRACT:
Cyclic analogs of PTH and PTHrP wherein a disulfide or amide bond links the side chains of residues A.sub.13 and A.sub.17, A.sub.26 and A.sub.30, or A.sub.13 and A.sub.17 and A.sub.26 and A.sub.30.

REFERENCES:
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Chorev et al.; Cyclic Parathyroid Hormone Related Protein Antagonists: Lactamization; Biochem.; 1991; 30;5968-5974.
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Albert et al.; Patent 190 GB2269176-A; 1994.
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Chorev et al., "Cyclic Parathyroid Hormone Related Protein Antagonists: Latamization", Biochemistry 30:5968-5974, 1991.
Neugebauer et al., "Structure and Protein Kinase C Stimulating Activities of Lactam Analogues of Human Parathyroid Hormone Fragment", Int. J. Peptide Protein Res. 43:555-562, 1994.
Broadus et al., "Parathyroid Hormone-related Protein", The Parathyroid, Chapter 17, pp. 259-294, 1994.
Dempster et al., "Anabolic Actions of Parathyroid Hormone on Bone", Endocrine Reviews, 14:690-709, 1993.
Hesch et al., "Increase of Vertebral Density by Combination Therapy with Pulsatile 1-38hPTH and Sequential Addition of Calcitonin Nasal Spray in Osteoporotic Patients", Calcif Tissue Int, 44:176-180, 1989.
Nissenson et al., "Structure and Function of the Receptor for Parathyroid Hormone and Parathyroid Hormone-Related Protein", Humana Press Inc., 3:193-202, 1993.
B. Lawrence Riggs, M.D., "Treatment of Osteoporosis with Sodium Fluoride or Parathyroid Hormone", The American Journal of Medicine, 91 (suppl 5B), 5B-37S-5B-41S, 1991.
Slovik et al., "Restoration of Spinal Bone in Osteoporotic Men by Treatment with Human Parathyroid Hormone (1-34) and 1,25-Dihydroxyvitamin D", Journal of Bone and Mineral Res., 1:377-381, 1986.

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