Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1994-04-08
1998-12-01
Kight, III, John
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
536 2613, A61K 3170, C07H 19213
Patent
active
058439161
ABSTRACT:
A method of inhibiting the proliferation of cells, particularly cancerous cells, by contacting the cells with a phosphorothioate derivative of a cAMP modified at either or both the C-6 and C-8 positions of the adenine moiety, and pharmaceutical compositions therefor.
REFERENCES:
patent: 3849397 (1974-11-01), Robins, I et al.
patent: 3948886 (1976-04-01), Shuman et al.
patent: 4058659 (1977-11-01), Robins, II et al.
patent: 4208406 (1980-06-01), Lapinet et al.
Genieser et al.(II), "Derivatives of 1.beta.-D-ribofuranosylbenzimidazole 3', 5'-phosphate That Mimic the Actions of Adenosine 3 ', 5'-phosphate (cAMP) and Guanosine 3', 5'-phosphate (cGMP),"Carbohydrate Research,234, 217-235 (1992).
Kano et al., "The Activation of cAMP-dependent Protein Kinase Is Directly Linked to the Reulation of Osteoblast Proliferation (UMR-106) by Parathyroid Hormone,"Biochem. Biophys. Res. Comm., 177(1), 365-369 (1991).
Yokozaki et al., "Unhydrolyzable Analogues of Adenosine 3:5 -Monophosphate Demonstrating Growth Inhibition and Differentiation in Human Cancer Cells, " Cancer Research,52, 2504-2508 (1992).
Beardsley, "Trends in Cancer Epidemiology; A War Not Won," Scientific American 270 (1), 130-138 (1994)
Ally et al., "Selective Modulation of Protein Kinase Isozymes by the Site-Selective Analog 8-Chloroadenosine 3', 5'-Cyclic Monophosphate Provides a Biological Means for control of Human Colon Cancer Cell Growth," Proc. Nat. Acad. Sci. USA,85, 6319-6322 (Sept. 1988).
Clair et al., "Site-Selective cAMP Analogs Induce Nuclear Translocation of the RII cAMP Receptor Protein in Ha-MuSV-Transformed NIH/ 3T3 Calls," FEBS Letters, 224(2), 337-384 (Nov.1987).
Cho-chung et al.(I), "Site-Selective Cyclic AMP Analogs as New Biological Tools in Growth Control, Differentiation, and Proto-oncogene Regulation," Cancer Invest.,7(2), 161-177 (1989).
Cho-chung et al.(II),"Role of Site-Selective cAMP Analogs in the Control and Reversal of Malignancy,"Pharmac. Ther., 50, 1-33 (1991).
Cho-chung et al.(III),"Role Cyclic AMP Receptor Proteins in Growth, Differentiation, and Suppression of Malignancey: New Approaches to Therapy, " Cancer Res.,50, 7093-7100 (Nov. 1990).
Cho-Chung(II), "Site-Selective 8-Chloro-Cyclic Adenosine 3 ', 5'-Monophosphate as a Biologic Modulator of Cancer: Restoration of Normal Control Mechanisms," J. Nat'l Cancer Inst.,81 (13), PP. (July 5, 1989).
Cho-chung et al.(IV), "In Vivo Inhibition of Growth of Two Hormone Dependent Mammary Tumors by Dibutyryl1 Cyclic AMP," Science,183, 87-88 (Jan. 1974).
Dostmann et al., "Probing the Cyclic Nucleotide Binding Sites of cAMP-Dependent Protein Kinases I and II with Analogs of Adenosine 3',5'-Cyclic Phosphorothioates, " J. Biol. Chem.,265(18), 10484-10491 (1990).
Geniesser et al., "Synthesis of Nucleoside-3', 5'-Cyclic Phosphorothioates by Cyclophosphorylation of Unprotected Nucleosides, " Tetrahedron Letters,29(23), 2803-2804 (1988).
Helson et al., "A Rationale for the Treatment of Metastatic Neuroblastoma," J. Nat'l Cancer Inst.,57(3), 727-729 (Sept. 1976).
Holmgren et al., "In Vivo Modulation of Intracellular cAMP and Cell Growth of a Lymphatic Tumour in Mice by Cholera Toxin," Exp. Cell Res.,108, 31-39 (1977).
Katsaros et al., "Site-Selective Cyclic AMP Analogs Provide a New Approach in the Conrol of Cancer Cell Growth," FEBS Letters,223(1), 97-103 (Oct. 1987).
O'Brian et al., "A Kinetic Study of Interactions of (Rp)-and (Sp)-Adenosine Cyclic 3', 5'-Phosphorothioates with Type II Bovine Cardiac Muscle Adenosine Cyclic 3', 5'-Phosphate Dependent Protein Kinase," Biochemistry,21, 4371-4376 (1982).
Ogreid et al.(I), "Activation of Protein Kinase Isozymes by Cyclic Nucleotide Analogs Used Singly or in Combination," Eur. J. Biochem., 150, 219-227 (1985).
Ogreid et al.(I), "Comparison of the Two Classes of Binding Sites (A and B) of Type I and Type II Cyclic-AMP-Dependent Protein Kinases by Using Cyclic Nucleotide Analogs, ", Eur. J. Biochem., 181, 19-31 (1989).
Ogreid et al.(I),"Comparison of the Two Classes of Binding Sites (A and B) of Type I and Type II Cyclic-AMP-Dependent Protein Kinases by Using Cyclic Nucleotide Analogs," Eur. J. Biochem., 181, 19-31 (1989).
Cho-Chung et al.(V), "Site-Selective cAMP Analogs are Cytostatic and Differentiating Agents for a Spectrum of Human Cancer Cell Lines: Potential for Application to Chemotherapy," Proc. of ASCO, 6, Abstract No. 62 (Mar. 1987).
Prasad, "Differentiation of Neuroblastoma Cells in Culture," Biol. Rev.,50, 129-265 (1975).
Rannels et al., "Two Different Intrachain cAMP Binding Sites of cAMP-Dependent Protein Kinases," J. Biol. Chem., J. Biol, Chem.,255(15), 7085-7088 (1980).
Robinson-Steiner et al., "Probable Involvement of Both Intrachain cAMP Binding Sites in Activation of Protein Kinase," J. Biol. Chem., 258(2), 1032-1040 (1983).
Tagliaferri et al.(I), "Two Classes of cAMP Analogs Synergistically Inhibit p21 ras Protein Synthesis and Phenotypic Transformation of NIH/3T3 Cells Transfected with Ha-MuSV DNA," Biochem. Biophys. Res. Comm.,130(3), 1193-1200 (Aug. 1985).
Tagliaferri et a.(II), "Synergistic Inhibition of Growth of Breast and Colon Human Cancer Cell lines by Site-Selective Cyclic AMP Analogs, "Cancer Res., 48, 1642-1650 (Mar. 1988).
Tagliaferri et al.(III), "Reverse Transformation of Harvey Murine Sarcoma Virus-Transformed NIH/3T3 Cells by Site-Selective Cyclic AMP Analogs,"J. Biol, Chem., 263 (1), 409-416 (1988)
Tortora et al., "Site-Selective cAMP Analogs at Micromolar Concentrations Induce Growth Arrest and Differentiation of Acute-Promyelocytic, Chronic Myelocytic, and Acute Lymphocytic Human Leukemia Cell Lines," Blood,71(1), 230-233 (Jan. 1988).
Tsuji et al., "Neuronal Differentiation of Oat Cell Carcinoma In Vitro by Dibutyryl Cyclic Adenosine 3',5'-Monophosphate,"Cancer Letters, 1, 311-318 (1976).
Cho-Chung Yoon Sang
Genieser Hans-Gottfried
Jastorff Bernd
Crane L. Eric
Kight III John
The United States of America as represented by the Department of
LandOfFree
Cyclic amp analogues, individually and in pairs, to inhibit neop does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Cyclic amp analogues, individually and in pairs, to inhibit neop, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cyclic amp analogues, individually and in pairs, to inhibit neop will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2395716