Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1999-02-01
2000-10-31
Chang, Ceila
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514322, 514329, 546199, 546210, 546212, 546213, 546214, 546224, A61K 31445, C07D40910
Patent
active
061403490
ABSTRACT:
The present invention is directed to cyclic amines of the formula I: ##STR1## (wherein R.sup.1, R.sup.2, R.sup.3, m and n are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-1, CCR-2, CCR-2A, CCR-2B, CCR-3, CCR-4, CCR-5, CXCR-3, and/or CXCR-4.
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Caldwell Charles G.
Finke Paul E.
Kim Dooseop
Kothandaraman Shankaran
Maccoss Malcolm
Chang Ceila
Merck & Co. , Inc.
Rose David L.
Thies J. Eric
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