Cyclic amine modulations of chemokine receptor activity

Details Cyclic amine modulations of chemokine receptor activity Cyclic amine modulations of chemokine receptor activity

1998-07-21

2000-10-24

Chang, Ceila

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544188, 544193, 544194, 544199, 544201, 544207, 544208, 544209, 544214, 544217, 544221, 544223, 544225, 544228, 544229, 544231, 544234, 544331, 544336, 544405, 544408, 544409, 514252, 514255, 514318, 514319, 514322, 514323, 514324, 514327, 514330, 514331, A61K 31445, C07D21156

Patent

active

06136827&

ABSTRACT:
The present invention is directed to cyclic amines of the formula I: ##STR1## (wherein R.sup.1, R.sup.2, R.sup.3, m and n are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-1, CCR-2, CCR-2A, CCR-2B, CCR-3, CCR-4, CCR-5, CXCR-3, and/or CXCR-4.

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