Cyclic amine derivatives of substituted quinoxaline 2,3-diones a

Details Cyclic amine derivatives of substituted quinoxaline 2,3-diones a Cyclic amine derivatives of substituted quinoxaline 2,3-diones a

1995-06-07

1999-02-23

Berch, Mark L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514249, 514250, 540599, 544343, C07D40306, A61K 31495

Patent

active

058744266

ABSTRACT:
A novel series of substituted quinoxaline 2,3-diones of Formula I ##STR1## useful as neuroprotective agents are taught. Novel intermediates, processes of preparation, and pharmaceutical compositions containing the compounds are also taught. The compounds are glutamate antagonists and are useful in the treatment of stroke, cerebral ischemia, or cerebral infarction resulting from thromboembolic or hemorrhagic stroke, cerebral vasospasms, hypoglycemia, cardiac arrest, status epilepticus, perinatal asphyxia, anoxia, seizure disorders, pain, Alzheimer's, Parkinson's, and Huntington's Diseases.

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