Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1999-02-25
2000-07-11
Huang, Evelyn Mei
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514210, 514212, 5142275, 5142315, 514255, 514299, 514304, 514424, 540604, 544 59, 544158, 544384, 546112, 546129, 546221, 548556, 548952, 548965, A61K 31445, A61K 3146, A61K 3140, C07D21154, C07D20712, C07D20504
Patent
active
060873795
ABSTRACT:
A cyclic amine derivative represented by the following formula: ##STR1## wherein R.sup.1 represents a substituted or unsubstituted phenyl group, R.sup.2 represents a substituted of unsubstituted C.sub.1 -C.sub.8 aliphatic acyl group, a substituted or unsubstituted benzoyl group or a C.sub.1 -C.sub.4 alkoxycarbonyl group, and R.sup.3 represents a substituted 3 to 7 membered saturated cyclic amino group which may form a fused ring; or pharmaceutically acceptable salts thereof. The compounds and salts have excellent platelet aggregation inhibitory action. They are useful for the treatment and prevention of such diseases as embolism, thrombosis or arteriosclerosis and for the preparation of pharmaceutical compositions for such uses.
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P. Lumley et al, "A Method for Quantitating Platelet Aggregation and Analyzing Drug-Receptor Interactions on Platelets in Whole Blood in Vitro", J. Pharmacol. Methods, vol. 6, pp. 153-166 (1981).
G.V.R. Born, "Aggregation of Blood Platelets by Adenosine Diphosphate and its Reversal", Nature, vol. 194, No. 4832, pp. 927-929 (Jun. 1962).
Asai Fumitoshi
Ikeda Toshihiko
Inoue Teruhiko
Iwamura Ryo
Kita Jun'ichiro
Huang Evelyn Mei
Sankyo Company Limited
Ube Industries Ltd.
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