Cyclic amine derivative having heteroaryl ring

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C514S252010, C514S255030, C514S256000, C514S316000, C514S323000, C514S326000, C514S331000, C544S238000, C544S333000, C544S405000, C546S194000, C546S201000, C546S209000, C546S210000

Reexamination Certificate

active

07829580

ABSTRACT:
A compound having the general formula (I)wherein R1represents C1-C6 alkyl, etc., R2represents hydrogen, C2-C7 alkanoyl, C7-C11 arylcarbonyl, the formula R4—(CH2)l—, etc., R3represents C6-C10 aryl, etc., X1, X2, X3, X4and X5each independently represents hydrogen, halogen, etc., and n represents an integer of 0 to 2, pharmacologically acceptable salts thereof or prodrugs thereof. They have excellent inhibition of platelet activation, etc. and are useful as a prophylactic or therapeutic agents for diseases related to thrombus or embolus formation.

REFERENCES:
patent: 5750754 (1998-05-01), Mills
patent: 6087379 (2000-07-01), Asai et al.
patent: 6610708 (2003-08-01), Asai et al.
patent: 2004/0254376 (2004-12-01), Suzuki et al.
patent: 2006/0270706 (2006-11-01), Kimura et al.
patent: 2009/0306059 (2009-12-01), Kimura et al.
patent: 11-310570 (1999-11-01), None
patent: 11-315020 (1999-11-01), None
patent: 3088016 (2000-07-01), None
patent: 10-120649 (2002-02-01), None
patent: 2007-001974 (2007-11-01), None
patent: WO 94/22835 (1994-10-01), None
patent: WO 02/085850 (2002-10-01), None
Wyngaarden et al. “Cecil Textbook of medicine” p. 247 (1983).
definition “prodrug” MedicieNet.com (2009) (1 page from internet).
Kimura et al. “preparation of cyclic amine . . . ” CA 145:505461 (2006).
Kimura et al “Preparation of cyclic amine . . . ” CA 146:121973 (2007).
Kimura et al. “preparation of cyclic amine . . . ” CA 149:128750 (2008).
Web definition of prodrug (2010).
International Search Report for International Application No. PCT/JP2004/017974, date of mailing International Search Report: Feb. 15, 2005.
U.S. Appl. No. 11/915,522, filed Nov. 26, 2007, Kimura, et al.
Supplementary European Search Report for European Application No. 06 74 6885 as issued Mar. 11, 2010; which is the European application of the related U.S. Appl. No. 11/915,522.
English Abstract of JP 11-315052.
Search Report and Written Opinion for Singapore Application No. 200718118-3 as issued May 26, 2009; which is the Singapore application of the related U.S. Appl. No. 11/915,522.
Sugidachi, A., et al., “Antiplatelet action of R-99224, an active metabolite of a novel thienopyridine-type Gi-linked P2T antagonist, CS-747”, British Journal of Pharmacology (2001), 132, pp. 47-54.
Sugidachi, A., et al., “The in vivo pharmacological profile of CS-747, a novel antiplatelet agent with platelet ADP receptor antagonist properties”, British Journal of Pharmacology (2000), 129, pp. 1439-1446.
Pereillo, J., et al., “Structure and Stereochemistry of the Active Metabolite of Clopidogrel”, Drug Metabolism and Disposition, 2002, The American Society of Pharmacology and Experimental Therapeutics, DMD 30, pp. 1288-1295.
Born et al., “The aggregation of Blood Platelets.”The Journal of Physiology, vol. 168, 178, 1963.
T. W. Green et al., “Protective Groups in Organic Synthesis, Third Edition”, John Wiley & Sons, Inc. (1999)—in particular pp. 17-245 and 369-493.
S. Reddy, et al.: Tetrahedron Letters, 41: 6285-6288, (2000).
Caprie Steering Committee. “A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (Caprie)”,The Lancet, 348:1329-39 (1996).
“Cecil Textbook of Medicine” sixteenth edition; eds. Wyngaarden, J.B. and Smith L.H.; W.B. Saunders Company. p. 247. (1983).
English Translation of the International Preliminary Report on Patentability together with the Written Opinion of the International Search Authority as issued in Application PCT/JP2004/017974, dated Jul. 24, 2006; which is the corresponding PCT application.
International Search Report as issued in Application PCT/JP2004/017974, dated Feb. 15, 2005; which is the corresponding PCT application.
English Translation of the International Preliminary Report on Patentability together with the Written Opinion of the International Search Authority as issued in Application PCT/JP2006/310556, dated Nov. 29, 2007; which is the International application of the related U.S. Appl. No. 11/915,522.
International Search Report as issued in Application PCT/JP2006/310556, dated Jul. 25, 2006; which is the International application of the related U.S. Appl. No. 11/915,522.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Cyclic amine derivative having heteroaryl ring does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Cyclic amine derivative having heteroaryl ring, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cyclic amine derivative having heteroaryl ring will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4184749

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.