Cyclic amine compounds and their use

Details Cyclic amine compounds and their use Cyclic amine compounds and their use

1993-12-22

1995-08-15

Chang, Ceila

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514212, 514316, 540597, 546189, 546208, A61K 31445, C07D40104

Patent

active

054419670

ABSTRACT:
1. A cyclic amine compound of the formula ##STR1## wherein B means a saturated or unsaturated 5- to 7-membered aza-heterocyclic group which may be substituted; A means a bond or an alkylene or alkenylene group which may be substituted by hydrocarbon residues, oxo, hydroxyimino, and/or hydroxy, .sub.-- means either a single bond or a double bond (provided that when A means a bond, .sub.-- means a single bond); R.sub.2 and R.sub.3 independently mean a hydrogen atom or a hydrocarbon residue which may be substituted (provided that both of R.sub.2 and R.sub.3 are not hydrogen atoms) or jointly form a cyclic amino group together with the adjacent nitrogen atom, n is 0, 1 or 2 and p is 1 or 2 or a physiologically acceptable salt thereof.
The compounds are useful for therapy of cerebral edema, acute symptoms in cerebral apoplexy and protection of brain and nerve cell, or useful as anticholinesterase or as brain function-improving agent.

REFERENCES:
patent: 2686784 (1954-08-01), Finkelstein et al.
patent: 3729475 (1973-04-01), Williamson et al.
patent: 3927011 (1975-12-01), Nakanishi et al.
patent: 3931195 (1976-01-01), Dystra et al.
patent: 4294841 (1981-10-01), Champseix et al.
patent: 4868194 (1989-09-01), Carr et al.
Hermant et al "Systematic study of a series of highly fluorescent rod-shaped donor-acceptor systems" CA 112:97919 (1990).
Coombs et al "Synthesis and anti imflamatory activity at t-Aminomethylbenzopheone" J. Med. Chem. 14 1072-1074 (1971).
Dykstra et al "Lysergic Acid and Quinidine Analogs" J. Med. Chem. 16 1015-1020 (1973).
Villani et al., "Hypocholesteremic Agents. I. Substituted Stilbazoles and Dihydrostilbazoles", J. Med. Chem. 13(3) 359-366 (1970).
Tesfaye et al., Chemical Abstracts, 113: 118654a (1990), p. 723.

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