Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1989-04-12
1991-09-10
Lee, Mary C.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
540451, 546201, 548495, 514323, 514414, A61K 3155, C07D22500, C07D40100, C07D20918
Patent
active
050474022
ABSTRACT:
This invention provides a series of novel cyclic amides of formula I in which the group >Z--Y--X< is selected from >C.dbd.CH--N<, >N-CH.dbd.CH<, >C.dbd.N--N< and >N--N.dbd.C< and the other radicals have the meanings defined in the following specification. The compounds of formula I are leukotriene antagonists. The invention also provides pharmaceutically acceptable salts of the formula I compounds; pharmaceutical compositions containing the formula I compound, or their salts, for use in the treatment of, for example, allergic or inflammatory diseases, or endotoxic or traumatic shock conditions; and processs for the manufacture of the formula I compounds, as well as intermediates for use in such manufacture.
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ICI Americas Inc.
Jackson Thomas E.
Lee Mary C.
Miano Rosemay M.
Whittenbaugh Robert C.
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