Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1996-09-26
1998-01-06
Chang, Ceila
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546141, 546148, A61K 3147, C07D21724
Patent
active
057055050
ABSTRACT:
Compounds of formula I ##STR1## wherein Q.sup.1, Q.sup.2, Q.sup.3, and Q.sup.4 have any of the meanings given in the specification, their N-oxides, and their pharmaceutically acceptable salts are nonpeptide antagonists of neurokinin A and useful for the treatment of asthma, etc. Also disclosed are pharmaceutical compositions, processes for preparing the compounds of formula I and intermediates.
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patent: 5340822 (1994-08-01), Emonds-Alt et al.
patent: 5411971 (1995-05-01), Edmonds-Alt et al.
patent: 5576333 (1996-11-01), Miller
X. Emonds-Alt et al., "Pharmacological Profile and Chemical Synthesis of SR 48968, a Non-Peptide Antagonist of the Neurokinin A (NK2) Receptor", Biorganic & Medicinal Chemistry Letters, (1993), vol. 3, No. 5, 925-930.
Jacobs Robert Toms
Miller Scott Carson
Ohnmacht, Jr. Cyrus John
Shenvi Ashokkumar Bhikkappa
Veale Chris Allan
Chang Ceila
Darkes Paul R.
Harris Robert J.
Zeneca Limited
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