Cyclic amide derivatives for treating asthma

Details Cyclic amide derivatives for treating asthma Cyclic amide derivatives for treating asthma

1994-12-12

1996-12-31

Chang, Ceila

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5142242, 5142265, 5142272, 5142282, 5142338, 5142345, 5142355, 514320, 514321, 514322, 544 6, 544 50, 544 62, 544 70, 544122, 544129, 544230, 544239, 544242, 544253, 544360, 544363, 546 16, 546141, 546197, 546198, 546200, 546201, A61K 31445, C07D4016, C07D40114

Patent

active

055894895

ABSTRACT:
Compounds of formula I ##STR1## wherein Q.sup.1, Q.sup.2, Q.sup.3, and Q.sup.4 have any of the meanings given in the specification, their N-oxides, and their pharmaceutically acceptable salts are nonpeptide antagonists of neurokinin A and useful for the treatment of asthma, etc. Also disclosed are pharmaceutical compositions, processes for preparing the compounds of formula I and intermediates.

REFERENCES:
patent: 5102667 (1992-04-01), Dubroeucq et al.
patent: 5236921 (1993-08-01), Emonds-Alt et al.
patent: 5340822 (1994-08-01), Edmonds-Alt et al.
patent: 5411971 (1995-05-01), Edmonds-Alt et al.
X. Emonds-Alt et al., "Pharmacological Profile and Chemical Synthesis of SR 48968, a Non-Peptide Antagonist of the Neurokinin A (NK.sub.2) Receptor", Biorganic & Medicinal Chemistry Letters, (1993), vol. 3, No. 5, 925-930.

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