Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-11-26
1999-10-12
Chang, Celia
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514212, 514218, 514274, 514316, 514322, 514326, 540485, 540492, 544315, 546193, 546199, 546200, 546208, A61K 31445, C07D40114
Patent
active
059655763
ABSTRACT:
Compounds of formula I ##STR1## wherein Q.sup.1, Q.sup.2, Q.sup.3, and Q.sup.4 have any of the meanings given in the specification, their N-oxides, and their pharmaceutically acceptable salts are nonpeptide antagonists of neurokinin A and useful for the treatment of asthma, etc. Also disclosed are pharmaceutical compositions, processes for preparing the compounds of formula I and intermediates.
REFERENCES:
patent: 5567700 (1996-10-01), Miller
patent: 5677317 (1997-10-01), Miller
Maggi et al. "Tachykinin receptors and tachykinin receptor antagonists" J. Auton. Pharmc. v.13 pp. 23-93 (relevant pages only), 1993.
Jacobs Robert Toms
Miller Scott Carson
Ohnmacht, Jr. Cyrus John
Shenvi Ashokkumar Bhikkappa
Veale Chris Allan
Chang Celia
Person Richard V.
Zeneca Limited
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