Cyclic amide derivative, and its production and use

Details Cyclic amide derivative, and its production and use Cyclic amide derivative, and its production and use

2005-05-20

2010-06-29

Chang, Celia (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C514S274000

Reexamination Certificate

active

07745623

ABSTRACT:
The present invention provides a cyclic amide derivative useful as a drug for treating thrombosis, which is represented by the formula (I):wherein R1represents an optionally substituted cyclic hydrocarbon group or an optionally substituted heterocyclic group, W represents a bond or an optionally substituted divalent chain hydrocarbon group, a represents 0, 1, or 2, X1represents an optionally substituted lower alkylene or an optionally substituted lower alkenylene, Y1represents —C(O)—, —S(O)— or —S(O)2—, A represents a piperazine ring which may be further substituted or a piperidine ring which may be further substituted, X2represents a bond or an optionally substituted lower alkylene, Y2represents —C(O)—, —S(O)—, —S(O)2— or —C(═NR7)—, X3represents an optionally substituted C1-4alkylene or an optionally substituted C2-4alkenylene, Z3represents —N(R4)—, —O— or a bond, Z1represents —C(R2)(R2′)—, —N(R2)—, etc., and Z2represents —C(R3)(R3′)—, —N(R3)—, etc., or a salt thereof.

REFERENCES:
patent: 4147786 (1979-04-01), Huebner
patent: 4329348 (1982-05-01), Huebner
patent: 4695575 (1987-09-01), Janssens et al.
patent: 5559232 (1996-09-01), Ackermann et al.
patent: 5889024 (1999-03-01), Miller et al.
patent: 5965559 (1999-10-01), Faull et al.
patent: 6105581 (2000-08-01), Eggers et al.
patent: 6204265 (2001-03-01), Reichard et al.
patent: 6359134 (2002-03-01), Tawada et al.
patent: 6403595 (2002-06-01), Tawada et al.
patent: 6423519 (2002-07-01), Bergnes et al.
patent: 6518538 (2003-02-01), Barnabei
patent: 6541488 (2003-04-01), Bernat et al.
patent: 6562828 (2003-05-01), Katoh et al.
patent: 6596754 (2003-07-01), Hara et al.
patent: 6629974 (2003-10-01), Penny et al.
patent: 6723091 (2004-04-01), Goble et al.
patent: 2002/0045616 (2002-04-01), Stein et al.
patent: 2003/0187023 (2003-10-01), Kubo et al.
patent: 2004/0006062 (2004-01-01), Smallheer et al.
patent: 2004/0077635 (2004-04-01), Qiao et al.
patent: 2004/0254175 (2004-12-01), Dorsch et al.
patent: 2005/0101595 (2005-05-01), Chu et al.
patent: 2005/0203127 (2005-09-01), Cezanne et al.
patent: 2005/0282808 (2005-12-01), Kawaguchi et al.
patent: 2007/0004736 (2007-01-01), Kubo et al.
patent: 0 798 295 (1997-10-01), None
patent: 1 043 311 (2000-10-01), None
patent: 1 048 652 (2000-11-01), None
patent: 1 054 005 (2000-11-01), None
patent: 1 104 754 (2001-06-01), None
patent: 1 188 755 (2002-03-01), None
patent: 1 191 028 (2002-03-01), None
patent: 1 188 755 (2003-03-01), None
patent: 1 564 213 (2005-08-01), None
patent: 50-11391 (1975-04-01), None
patent: 5-208946 (1993-08-01), None
patent: 7-112970 (1995-05-01), None
patent: JO2002-201178 (2002-07-01), None
patent: WO 95/00507 (1995-01-01), None
patent: WO 96/10022 (1996-04-01), None
patent: WO 96/13262 (1996-05-01), None
patent: WO 96/16940 (1996-06-01), None
patent: WO 99/26919 (1996-06-01), None
patent: WO 96/40679 (1996-12-01), None
patent: WO 97/21437 (1997-06-01), None
patent: WO 97/29104 (1997-08-01), None
patent: WO 98/23279 (1998-06-01), None
patent: WO 98/54164 (1998-12-01), None
patent: WO 98/56365 (1998-12-01), None
patent: WO 99/09027 (1999-02-01), None
patent: WO 99/26924 (1999-06-01), None
patent: WO 99/33805 (1999-07-01), None
patent: WO 00/09480 (2000-02-01), None
patent: WO 00/13707 (2000-03-01), None
patent: WO 00/18398 (2000-04-01), None
patent: WO 00/39114 (2000-07-01), None
patent: WO 00/78747 (2000-12-01), None
patent: WO 01/02397 (2001-01-01), None
patent: WO 01/07436 (2001-02-01), None
patent: WO 01/17992 (2001-03-01), None
patent: WO 01/44172 (2001-06-01), None
patent: WO 01/77101 (2001-10-01), None
patent: WO 02/06234 (2002-01-01), None
patent: WO 02/26720 (2002-04-01), None
patent: WO 02/057223 (2002-07-01), None
patent: WO 02/068407 (2002-09-01), None
patent: WO 03/010160 (2003-02-01), None
patent: WO 03/022214 (2003-03-01), None
patent: WO 03/026652 (2003-04-01), None
patent: WO 03/039543 (2003-05-01), None
patent: WO 03/082847 (2003-10-01), None
patent: WO 2004/002477 (2004-01-01), None
patent: WO 2004/035579 (2004-04-01), None
patent: WO 2004/35579 (2004-04-01), None
patent: WO 2004/048363 (2004-06-01), None
patent: WO 2005/087266 (2005-09-01), None
patent: WO 2005/113504 (2005-12-01), None
Kubo et al. CA:136:134784 (2002).
Kubo et al. “Preparation of heterocyclic amides . . . ” Ca 144:22941 (2005).
Kubo et al. “preparation of hydrocarbyl . . . ” CA136:134784 (2002).
Zablocki et al. “Potent in vitro . . . ”.Journal Med. Chem., vol. 38, pp. 2378-2394 (1995).
Maduskuie et al. “Rational design and synthesis of novel, potent bis-phenylamidine carboxxylate factor Xa inhibitors”.Journal of Medicinal Chemistry, vol. 41, pp. 53-62 (1998).
Al-Obeidi et al. “Factor Xa Inhibitors”.Exp. Opin, Ther. Patents, vol. 9, No. 7, pp. 321-353 (1999).
Wyngaarden et al. “Cecil Textbook of Medicine”, pp. 247 (1983).
Patani et al. “Bioisosterism: A Ration al Approach in Drug Design”.Chem. Rev., vol. 96, pp. 3147-3176 (1996).
Rubini et al. “Synthesis of Isoteric Methylene-oxy Pseudodipeptide Analogues as Novel Amide Bond Surrogate Units”.Tetrahedron, vol. 42, No. 21, pp. 6039-6045 (1986).
Mitsubishi Chemical Industries Co., Ltd. “Alkylenedioxybenzene derivatives”. CA 100:103390 (1984).
Szporny et al. “Process for production of phenylsulfonylpropionic acid derivatives useful for inhigition of somach acid secretion and pharmaceutical compositions comprising them”. CA 123:284907 (1995).
Toldy et al. “Preparation of pyrimidinylpiperazines as lipid peroxidation inhibitors”. CA 126:343579 (2004).
Faull et al. “Preparation of aminoheterocyclic derivatives as antithrombotic or anticoagulant agents”. CA 125:114690 (1996).
Kubo et al. “Preparation of hydrocarbyl sulfone derivatives as inhibitors of activated blood coagulation factor X and process for their production”. CA 136:134784 (2002).
Kubo et al. “Preparation of imidazopyridine derivatives as activated blood coagulation factor X inhibitors for treatment of thrombosis”. CA 140:375175 (2004).
Kubo et al. “Preparation and imidazoles and their use as coagulation factor Xa inhibitors”. CA 144:128976 (2006).
Kubo et al. “Preparation of heterocyclic amides as activated blood coagulation factor X inhibitors for use as antithrombotic agents”. CA 144:22941 (2005).
Faull et al. Preparation of aminoheterocyclic derivatives as antithrombotic or anticoagulant agents. CA 125:114690 (1996).
Patani et al. Bioisosterism: A Rational Approach in Drug Design, 1996, Chemical Review, 96, 3147-3176.
Wolff, Manfred E. “Burger's Medicinal Chemistry, 5ed, Part I”. John Wiley & Sons, 1995, pp. 975-977.
Banker (Modern Pharmaceuticals) Banker, G.S. et al. “Modern Pharmaceuticals 3ed.”, Marcel Dekker, New York, 1996, pp. 451 and 596.

Affiliated with

Also associated with

Rating

Cyclic amide derivative, and its production and use does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Cyclic amide derivative, and its production and use, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cyclic amide derivative, and its production and use will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4191714