Cyclic adenosine monophosphate 8-substituted derivatives

Details Cyclic adenosine monophosphate 8-substituted derivatives Cyclic adenosine monophosphate 8-substituted derivatives

1975-09-24

1977-09-13

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated via claimed linking group, bond, chelating agent,...

536 27, 536 28, A61K 3170, C07H 1920

Patent

active

040483070

ABSTRACT:
Novel cyclic adenosine monophosphate derivatives represented by the following general formula: ##STR1## wherein A stands for --S-- or --NH-- and n is an integer of from 2 to 12, ARE SUPERIOR TO KNOWN CYCLIC ADENOSIENE DERIVATIVES IN BIOLOGICAL AND PHARMACOLOGICAL ACTIVITIES, ESPECIALLY PDE-inhibiting activity and membrane permeability. Accordingly, these derivatives are very effective for remedying and controlling diseases caused by disorder of the intracellular cyclic adenosine monophosphate level, such as asthma and scabies. These derivaives can readily be synthesized by reacting an 8-halogeno cyclic adenosine monophosphate of the following general formula ##STR2## wherein X is a halogen atom such as bromine, with an alkali metal salt of a linear alkylmercaptan having 3 to 13 carbon atoms in the alkyl group or a linear alkylamine having 3 to 13 carbon atoms in the alkyl group.

REFERENCES:
patent: 3712885 (1973-01-01), Weimann et al.
patent: 3752805 (1973-08-01), Maguire et al.
patent: 3872098 (1975-03-01), Jones et al.
Boswell et al., Reprint from the Journ. of Heterocyclic Chem. 12, pp. 1-9, 1975.

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