Cyclcic FR-900520 microbial biotransformation agent

Details Cyclcic FR-900520 microbial biotransformation agent Cyclcic FR-900520 microbial biotransformation agent

1992-01-10

1993-06-22

Lilling, Herbert J.

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

435118, 435899, C12P 1716, C12R 156

Patent

active

052216250

ABSTRACT:
Described is a process for producing a new immunosuppressant, a C-19/C-22 cyclic hemiketal (Compound I) biotransformation analog of FR-900520, under novel fermentation conditions utilizing the novel microorganism, Streptomyces sp. (Merck Culture Collection MA6963) ATCC No. 55230. The macrolide immunosuppressant is useful in preventing human host rejection of foreign organ transplants, e.g. bone marrow, liver, lung, kidney and heart transplants.

REFERENCES:
patent: 3244592 (1966-04-01), Arai
patent: 4081531 (1978-03-01), Arai et al.
patent: 4242453 (1980-12-01), Umezawa et al.
patent: 4264607 (1981-04-01), Dewey et al.
patent: 4894344 (1990-01-01), Sugiyama et al.
"Catalogue of Bacteria and Phage" 17th ed. ATCC Ed. Gherna et al. 1989 p. 228 S. lavendulae.
J. Antibiotics A15, pp. 231-232, by Arai Jul. 31, 1962.

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