Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2006-01-03
2006-01-03
Pryor, Alton (Department: 1616)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S230500, C544S050000, C544S092000
Reexamination Certificate
active
06982261
ABSTRACT:
This invention provides a progesterone receptor antagonist of formula 1 having the structurewherein T is O, S, or absent; R1, and R2are each, independently, hydrogen, alkyl, substituted alkyl; or R1and R2are taken together form a ring and together contain —CH2(CH2)nCH2—, —CH2CH2CMe2CH2CH2—, —O(CH2)pCH2—, —O(CH2)qO—, —CH2CH2OCH2CH2—, or —CH2CH2NR7CH2CH2—;n=1–5; p=1–4; q=1–4;R3is hydrogen, OH, NH2, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, or CORA;RAis hydrogen, alkyl, substituted alkyl, alkoxy, substituted alkoxy, aminoalkyl, or substituted aminoalkyl;R4is hydrogen, halogen, CN, NH2, alkyl, substituted alkyl, alkoxy, substituted alkoxy, aminoalkyl, or substituted aminoalkyl;R5is hydrogen, alkyl, or substituted alkyl;R6is hydrogen, alkyl, substituted alkyl, or CORB;RBis hydrogen, alkyl, substituted alkyl, alkoxy, substituted alkoxy, aminoalkyl, or substituted aminoalkyl;R7is hydrogen or alkyl, or a pharmaceutically acceptable salt thereof.
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P. Pflegel
Collins Mark A.
Edwards James P.
Jones Todd K.
Mackner Valerie A.
Tegley Christopher M.
Howson and Howson
Ligand Pharmaceuticals Inc.
Pryor Alton
Wyeth
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