Cyanopyrrole containing cyclic carbamate and thiocarbamate...

Details Cyanopyrrole containing cyclic carbamate and thiocarbamate... Cyanopyrrole containing cyclic carbamate and thiocarbamate...

2011-08-23

2011-08-23

Wilson, James O (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

C544S092000, C544S105000, C548S561000

Reexamination Certificate

active

08003784

ABSTRACT:
Methods for preparing cyclic carbamates and thiocarbamates containing cyanopyrrole moieties and of the formula are provided.Z are the same or different and are H, optionally substituted C1to C6alkyl, or CORA; RAis H, optionally substituted C1to C6alkyl, optionally substituted C1to C6alkoxy, or optionally substituted C1to C6aminoalkyl; Q are the same or different and are H, OH, NH2, CN, halogen, optionally substituted C1to C6alkyl, optionally substituted C2to C6alkenyl, optionally substituted C1to C6alkynyl, optionally substituted C1to C6alkoxy, optionally substituted C1to C6aminoalkyl, or CORB; and RBis H, optionally substituted C1to C6alkyl, optionally substituted C1to C6alkoxy, or optionally substituted C1to C6aminoalkyl. Compounds including 2-amino-5-(5-cyano-1-methyl-1H-pyrrol-2-yl)benzoic acid methyl ester, 5-[4-amino-3-(1-hydroxy-1-methyl-ethyl)-phenyl]-1-methyl-1H-pyrrole-2-carbonitrile, and 2-amino-5-(5-cyano-1-methyl-1H-pyrrol-2-yl)-phenyl-ethanone, or pharmaceutically acceptable salts thereof, and the uses thereof are also provided.

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