Cyanomethylpyridine derivatives

Details Cyanomethylpyridine derivatives Cyanomethylpyridine derivatives

1994-03-23

1995-05-30

Tsang, Cecilia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514314, 544363, 546174, 546175, A61K 3147, A61K 31495, C07D29500, C07D40114

Patent

active

054201314

ABSTRACT:
The present invention relates to new cyanomethylpyridine dervatives of formula I ##STR1## wherein Y represents N or CH; R.sub.1 represents hydrogen, fluoro, chloro, difluoro or dichloro; R.sub.2 represents hydrogen or C.sub.1-4 alkyl; n is 0 or 1; p is 0 or 1; A represents a covalent bond or a group of formula --CONHCH(Ar)--, --NHCH(Ar)--, --SO.sub.2 NHCH(Ar)--, --NHCONHCH(Ar)-- or --OCONHCH(Ar)--, and when p is 1, A can also represent --CH(Ar)NH--; and Ar represents phenyl or phenyl substituted with halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy or trifluoromethyl. These compounds are PAF antagonist and/or 5-lipoxygenase inhibitors.

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