Cyanoisoalkylation of hydroxy substituted aryl compounds using k

Details Cyanoisoalkylation of hydroxy substituted aryl compounds using k Cyanoisoalkylation of hydroxy substituted aryl compounds using k

1987-01-02

1990-04-10

Siegel, Alan

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitriles

C07C12175

Patent

active

049162519

ABSTRACT:
A method for cyanoisoalkylating phenols or other hydroxy-substituted aryl compounds, which may have up to two substitutents ortho or para to the hydroxy moiety, comprising reacting a molar excess of phenol or aryl compound with a ketone in the presence of cyanide ion and hydroxide ion at an elevated temperature.
Compounds, such as 4-(1-cyano-1-methylethyl)phenol, produced via this method are useful as chemical intermediates in the preparation of polyurethanes, epoxy resins and pharmaceutical and agricultural products.

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Cotton "Advanced Inorganic Chem." 2nd ed. 1966 p. 312.
A. Johnsson, Act. Chem. Scand., 8, 1203-10 (1954).

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