Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-08-07
2007-08-07
Davis, Zinna N. (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C546S306000
Reexamination Certificate
active
10514500
ABSTRACT:
Pyridyl cyanoguanidine compounds of the general formula I wherein A, X1, X2, X3, Y1, Y2, Y3, R1, R2, R5, R6and n are as indicated in the description are suitable as prodrugs in human and veterinary therapy of proliferative diseases such as cancers.
REFERENCES:
patent: 5919816 (1999-07-01), Hausheer et al.
patent: 6525077 (2003-02-01), Binderup et al.
patent: 2003/0045515 (2003-03-01), Binderup et al.
patent: 2006/0014804 (2006-01-01), Binderup
patent: 0 660 823 (1996-08-01), None
patent: WO-98/54141 (1998-12-01), None
patent: WO-98/54142 (1998-12-01), None
patent: WO-98/54143 (1998-12-01), None
patent: WO-98/54144 (1998-12-01), None
patent: WO-98/54145 (1998-12-01), None
patent: WO-00/61559 (2000-10-01), None
patent: WO-00/61561 (2000-10-01), None
patent: WO-02/42265 (2002-05-01), None
patent: WO-02/094322 (2002-11-01), None
patent: WO-03/97601 (2003-11-01), None
patent: WO-03/097602 (2003-11-01), None
Davidsen et al., “N-(acyloxyalkyl) pyridinium salts as soluble prodrugs of a potent platelet activating factor antagonist”, Journal of Medicinal Chemistry, Dec. 23, 1994, vol. 37, No. 26, pp. 4423-4429.
Bodor et al., “Soft alkylating compounds as potential antitumor agents”, Journal of Medicinal Chemistry, 1980, vol. 23, No. 5, pp. 566-569.
Hjamaa, P. et al. “CHS 828, a Novel Pyridyl Cyanoguanidine with Potent Antitumor Activity in Vitro and in Vivo,” Cancer Research 59, 5751-5757, Nov. 15,1999.
Schou, C. et al. “Novel Cyanoguanidines with Potent Oral Antitumour Activity,” Bioorganic & Medicinal Chemistry Letters, vol. 7, No. 24, pp. 3095-3100, 1997.
Svensson, A. et al. “CHS 828 Inhibits Neuroblastoma Growth in Mice Alone and in Combination with Antiangiogenic Drugs,”Pediatric Research, vol. 51, No. 5, 2002, pp. 607-611.
Olsen, L.S. et al., “Anticancer Agent CHS 828 Suppresses Nuclear Facor-KB Activity in Cancer Cells through Downregulation of IKK Activity”,Int. J. Cancer,vol. 111, pp. 198-205, 2004.
Binderup Ernst Torndal
Duvold Tore
Davis Zinna N.
LEO Pharma A/S
Wilmer Cutler Pickering Hale and Dorr LLP
LandOfFree
Cyanoguanidine prodrugs does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Cyanoguanidine prodrugs, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cyanoguanidine prodrugs will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3831463