Cyanoguanidine derivative and process for preparation thereof

Details Cyanoguanidine derivative and process for preparation thereof Cyanoguanidine derivative and process for preparation thereof

1988-02-17

1989-12-12

Reamer, James H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

C78

Patent

active

048869104

ABSTRACT:
The present invention provides a cyanoguanidine derivtive which is a precursor for the synthesis of N-cyano-N'-methyl-N"-[2-{(5-methyl-1H-imidazol-4-yl)methylothio}ethyl]-gua nidine (Cimetidine) or its relted compound, which has an action of controlling secretion of acid in the stomach based on the histamine H.sub.2 receptor antagonism and is valuable as a drug for treating gastric ulcer. This cyanoguanidine derivative is prepared by reacting a haloketone derivative with an ammonium salt and a lower fatty acid salt or by reacting other cyanoguanidine derivative with an ammonium salt.

REFERENCES:
patent: 4276421 (1981-06-01), Baudet

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