Cyanoguanidine derivative and process for preparation thereof

Details Cyanoguanidine derivative and process for preparation thereof Cyanoguanidine derivative and process for preparation thereof

1987-09-01

1989-03-21

Hollrah, Glennon H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

548342, C07C12908

Patent

active

048145009

ABSTRACT:
A novel cyanoguanidine derivative represented by the following general formula (I): ##STR1## wherein X stands for a hydrogen atom, a chlorine atom or a bromine atom, and R stands for a lower alkyl group, is an effective precursor for the synthesis of N-cyano-N'-methyl-N"-(2-(5-methyl-4-imidazolylmethylthio(ethyl)-guanidine (Cimetidine) which has an action of controlling secretion of gastric acid and is valuable as an agent for the remedy of a gastric ulcer.
This cyanoguanidine derivative is prepared by reacting a methylvinylketone derivative with a mercaptoguanidine derivative or by reacting an amidinoketone derivative with a halogenating agent.

REFERENCES:
patent: 3950333 (1976-04-01), Durant et al.
Caldero, G. et al, "N-Cyano-N'-Methyl-2-[(5-Methyl, etc.]", C.A. 89, 146904g, Oct. 1978.

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