Cyanocobalamin derivatives

Details Cyanocobalamin derivatives Cyanocobalamin derivatives

1976-05-24

1978-04-04

Danison, Walter C.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260112R, 260112B, A23J 108, A23J 106

Patent

active

040827380

ABSTRACT:
The present invention is concerned with novel derivatives of cyanocobalamin (vitamin B.sub.12), especially of the monocarboxylic acid hydrolysates thereof, by which (1) an antigenic conjugate thereof with a protein is obtainable and (2) a readily iodinatable aromatic ring can be introduced while retaining in each instance, the essential constitution of cyanocobalamin to such an extent that (a) the antigenic protein conjugate, when introduced into the blood stream of a vertebrate, causes the formation of an antibody which is specific to the cyanocobalamin portion of the conjugate and (b) unmodified cyanocobalamin and the second-mentioned derivative when tagged or labeled with radioactive-iodine competitively bind on the aforementioned antibody. Thus, the present invention provides cyanocobalamin derivatives which are quite useful in radioimmunoassay (RIA) of vitamin B.sub.12.

REFERENCES:
patent: 3035983 (1962-05-01), Sherlock
patent: 3042588 (1962-07-01), Heathcote
Gregory et al., Nature, 173, p. 830 (1954).
Wijmenga et al., Chemical Abstracts, vol. 48:5315h (1954).
DiCarlo et al., Chemical Abstracts, vol. 67:2061c (1967).
Haffner et al., Chemical Abstracts, vol. 79:103,343z (1973).

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