Cyanoalkylpiperazines and methods for their preparation and use

Details Cyanoalkylpiperazines and methods for their preparation and use Cyanoalkylpiperazines and methods for their preparation and use

1982-08-11

1985-05-07

Hollrah, Glennon H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544230, 544402, C07D40304

Patent

active

045159475

ABSTRACT:
Novel cyanoalkylpiperazines are prepared by reacting piperazine with a haloalkylnitrile in the presence of an acid acceptor. The novel cyanoalkylpiperazines are advantageously employed to prepare 1-(cyanoalkyl)-4-(2-pyrimidyl)piperazines by reacting them with halopyrimidines in the presence of an acid acceptor.

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Lespagnol, et al., "Chemical Abstracts", vol. 59, 1963, col. 8740c.
Howard et al., J. Org. Chem., vol. 18, pp. 1484-1488 (1953).

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