Cyanoalkenylation process

Organic compounds -- part of the class 532-570 series – Organic compounds – Nitriles

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558351, 558352, C07C25308, C07C25310

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active

049945963

ABSTRACT:
1-Cyano-1-(4-alkylphenyl)alkenes having utility as chemical intermediates, especially in the preparation of ibuprofen and related pharmaceuticals, are prepared by reacting an alkylbenzene with an alkali metal cyanide and an acid halide in the presence of aluminum chloride.

REFERENCES:
patent: 3228831 (1966-01-01), Nicholson et al.
patent: 4536343 (1985-08-01), Ramachandran
patent: 4581176 (1986-08-01), Davidson
Noller, "Chemistry of Organic Compounds," 3rd Ed., (1965), p. 585, W. B. Saunders Co., Phila. & London.

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