Cyano naphthalene compounds

Organic compounds -- part of the class 532-570 series – Organic compounds – Nitriles

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558423, 544159, 544224, 546330, 546339, 548469, 548503, C07C25552

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055457444

ABSTRACT:
The invention relates to a process for preparing a substituted 2-amino-benz[cd]indole of the Formula I: ##STR1## The nitro group of a substituted 1-nitro-8-cyano-naphthalene compound is reduced to an amine group to form a substituted 1-amino-8-cyano-naphthalene compound, which is cyclized to form the substituted 2-amino-benz[cd]indole. The reduction and cyclization may be effected in a one-pot procedure using a reducing agent such as stannous chloride, which generates an acid that cyclizes the reduction product. The syntheses of the 1-nitro-8-cyano-naphthalene compound and its precursors are also described.

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Bowman et al., "1, 3, 4, 5-Tetrahydrobenz [cd] indoles and Related Compounds. Part III.," J. C. S. Perkin I: 438-442 (1973).
Chemical Abstracts, vol. 116, abstract No. 116:128566v, Mar. 30, 1992.

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