Cyano acetic acid anilide derivatives, process for their manufac

Details Cyano acetic acid anilide derivatives, process for their manufac Cyano acetic acid anilide derivatives, process for their manufac

1976-06-03

1977-12-06

Torrence, Dolph H.

Drug, bio-affecting and body treating compositions

Nonspecific immunoeffector, per se ; or nonspecific...

Bacterium or component thereof or substance produced by said...

260307H, 2603405R, 260465D, 260562K, 424304, A61K 3136, A61K 31275, C07C12178, C07D 1706

Patent

active

040617670

ABSTRACT:
A 2-hydroxyethylidene-cyano acetic acid anilide is prepared by heating an acetoacetic acid anilide with an orthoformic acid ester and acetic anhydride, isolating the resulting 2-alkoxymethylene-acetoacetic acid anilide and treating it with hydroxylamine and the isoxazole so obtained with a base, and optionally reacting the resulting alkali metal or ammonium salt with a mineral acid or a strong organic acid. The compounds of the invention have anti-inflammatory and analgesic activity.

REFERENCES:
patent: 2288863 (1942-07-01), Wenner
patent: 2721799 (1955-10-01), Edwards et al.
Dains et al., J. Am. Chem. Soc., vol. 35, pp. 965-969 relied on (1913).

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