Cyanine dyes with high-absorbance cross section as donor chromop

Details Cyanine dyes with high-absorbance cross section as donor chromop Cyanine dyes with high-absorbance cross section as donor chromop

1996-10-04

1998-12-29

Houtteman, Scott W.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

536 266, 536 2532, C12Q 168

Patent

active

058539921

ABSTRACT:
Cyanine dyes are used as the donor fluorophore in energy transfer labels in which light energy is absorbed by a donor fluorophore and transferred to an acceptor fluorophore which responds to the transfer by emitting fluorescent light for detection. The cyanine dyes impart an unusually high sensitivity to the labels thereby improving their usefulness in a wide variety of biochemical procedures, particularly nucleic acid sequencing, nucleic acid fragment sizing, and related procedures.

REFERENCES:
patent: 4996143 (1991-02-01), Heller et al.
patent: 5188934 (1993-02-01), Menchen et al.
patent: 5326692 (1994-07-01), Brinkley et al.
S-C. Hung et al. "Energy Transfer Primers with 5-or 6-Carboxyrhodamine-6G as Acceptor Chromophores," Analytical Biochemistry (1996) 238: 165-170.
S-C. Hung et al. "Cyanine Dyes with High Absorption Cross Section as Donor Chromophores in Energy Transfer Primers," Analytical Biochemistry (1996) 243: 15-27.
J. Ju et al. "Design and Synthesis of Fluorescence Energy Transfer Dye-Labeled Primers and Their Application for DNA Sequencing and Analysis," Analytical Biochemistry (1995) 231: 131-140.
Y. Wang, et al., "Rapid Sizing of Short Tandem Repeat Alleles Using Capillary Array Electrophoresis and Energy-Transfer Fluorescent Primers," Anal. Chem. (1995) 67: 1197-1203.
D.M. Sturmer, "Cyanine Dyes," Encyclopedia of Chemical Technology, Fourth Ed. (1993) John Wiley & Sons, Inc., 7: 782-809.

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