Cyanine dyes

Details Cyanine dyes Cyanine dyes

2006-02-07

2006-02-07

Stockton, Laura L. (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C548S455000

Reexamination Certificate

active

06995274

ABSTRACT:
A compound of the formula (I)wherein Z is O, S, or NR35wherein R35is H or alkyl; R1–R5are each independently H, alkyl, halo, carboxyl, amino, or SO3−Cat+, wherein Cat+is a cation and at least one of R1–R5is SO3−Cat+; R6and R7are each H, alkyl, or optionally, together with the (a) group to which they are bonded, form a ring; m and n are each independently integers from 0 to 5; X and Y are each independently O, S, Se or CR19R20, wherein R19and R20are each independently alkyl, or optionally form a ring together with the carbon atom to which they are bonded; R8and R13are each independently alkyl, (CH2)rR25or (CH2)rR18; wherein at least one of R8and R13(CH2)rR18and wherein r is an integer from 1 to 50, and R25is a functional group that does not directly react with a carboxyl, hydroxyl, amino, or a thiol group, and R18is a functional group that can react with a carboxyl, hydroxyl, amino, or thiol group; and R9–R12and R14–R17are each independently H, alkyl, halo, amino, sulfonato, R21COOH, R21OR22, R21SR22, or R21COOR22wherein R21is a bond or alkylene and R22is alkyl, or optionally R11and R12together with the atoms to which they are bonded form an aromatic ring, or optionally R16and R17together with the atoms to which they are bonded form an aromatic ring. Methods of dye-labeling biomolecules with the compound of formula (I) and dye-labeled biomolecules are also provided.

REFERENCES:
patent: 5268486 (1993-12-01), Waggoner et al.
patent: 5519145 (1996-05-01), Fabricius et al.
patent: 5556959 (1996-09-01), Brush et al.
patent: 5571388 (1996-11-01), Patonay et al.
patent: 6641798 (2003-11-01), Achilefu et al.
patent: 6642375 (2003-11-01), Inomata et al.
patent: 6649335 (2003-11-01), Missfeldt
patent: 6747159 (2004-06-01), Caputo et al.
patent: 2145405 (1995-02-01), None
patent: 43 26 466 (1995-02-01), None
patent: 580145 (1994-01-01), None
patent: 6-145539 (1994-05-01), None
patent: WO-97/13810 (1997-04-01), None
patent: WO-99/05221 (1999-02-01), None
patent: WO-00/16810 (2000-03-01), None
An English translation of JP 06-145539, May 24, 1994.
Narayanan, N., et al., A New Method For The Synthesis of Heptamethine Cyanine Dyes: Synthesis of New Near Infrared Fluorescent Labels, Journal of Organic Chemistry, American Chemical Society, 1995, pp. 2391-2395, vol. 60, XP 002065376, ISSN: 0022-3263.
Copy of International Search Report for PCT/US01/29385, dated Feb. 25, 2002.

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