Cyanide-free lytic reagent composition and method of use for...

Chemistry: analytical and immunological testing – Hemoglobin – myoglobin – or occult blood

Reexamination Certificate

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C436S008000, C436S010000, C436S017000, C436S063000, C436S164000, C436S166000, C436S174000, C435S002000, C252S408100

Reexamination Certificate

active

11125395

ABSTRACT:
A cyanide-free lytic reagent composition and method of use for measuring the total hemoglobin concentration and white blood cells in a blood sample are disclosed. The lytic reagent composition includes a quaternary ammonium surfactant to lyse red blood cells and release hemoglobin and a ligand to form a stable chromogen with the hemoglobin. The lytic reagent composition has a pH in a range of 3 to 10. The lytic reagent composition can also include a second quaternary ammonium surfactant. The ligand can be malic acid, malonic acid, ethylene diamine, N,N-diethylethylene diamine, N,N′-diethylethylene diamine, diethylene triamine, tetraethylene pentamine, 1,6-hexanediamine, 1,3-pentanediamine, 2-methylpentamethylenediamine, 1,2-diaminocyclohexane, 4-aminoacetophenone, bis-hexamethylenetriamine, pyridazine, or 3,6-dihyroxypyridazine.

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