Cyanamides useful as reversible inhibitors of cysteine...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C514S239200, C514S255010, C514S255060, C514S306000, C514S309000, C514S330000, C514S331000, C514S419000, C514S448000, C514S463000, C514S469000, C514S609000, C544S146000, C544S153000, C544S163000, C544S355000, C544S391000, C544S392000, C544S406000, C546S141000, C546S146000, C546S226000, C548S492000, C549S057000, C549S471000, C549S441000, C564S103000, C564S105000, C564S106000

Reexamination Certificate

active

06878706

ABSTRACT:
Compounds according to the following formula (I):wherein the variables Q and R1to R6are as described herein, which reversibly inhibit the cysteine proteases, such as cathepsins K, S, F, L and B; pharmaceutical compositions containing such compounds, and method of treating diseases and pathological conditions exacerbated by these cysteine proteases such as, but not limited to rheumatoid arthritis, multiple sclerosis and other autoimmune diseases, osteoporosis, asthma, Alzheimer's disease, atherosclerosis and endometriosis.

REFERENCES:
patent: 20030229226 (2003-12-01), Okamoto et al.
patent: WO 0049007 (2000-08-01), None
patent: WO 0177073 (2001-10-01), None

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