Cyanamide, alkoxyamino, and urea derivatives of...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C544S292000, C544S250000, C206S570000, C206S828000, C514S267000

Reexamination Certificate

active

06946469

ABSTRACT:
The present invention relates to 4,4-disubstituted-3,4-dihydro-2(1H)-quinazolinones of formula I:or stereoisomeric forms, stereoisomeric mixtures, or pharmaceutically acceptable salt forms thereof, wherein A is selected from NCN, NCONH2, and NOR9. The present invention relates to compounds which are useful as inhibitors of HIV reverse transcriptase, and to pharmaceutical compositions and diagnostic kits comprising the same, and methods of using the same for treating viral infection or as an assay standard or reagent.

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Houpis et al., Synthesis of a New Generation Reverse Transcriptase Inhibitor via the BC 13/GaCI3-Induced Condensation of Anillines with Nitriles (Sugasawa Reaction), Tetrahedron Letters, 1994, pp. 6811-6814, vol. 35, No. 7.
Tucker et al., Synthesis of a Series of 4-(Arylethynyl)-6-Chloro-4-Cyclopropyl-3,4-Dihydroquinazolin-2(1H)-Ones as Novel Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors, J. Med. Chem., 1994, pp. 2437-2444, vol. 37.
Huffman et al., Lithuum Alkoxides of Cinchona Alkaloids as Chiral Controllers for Enantioselective Acetylide Addition to Cyclic N-Acyl Ketimines, J. Org. Chem., 1995, pp. 1590-1594, vol. 60.
Erik De Clercq, “Perspectives of non-nucleoside reverse transcriptase inhibitors (NNRTIs) in the therapy of HIV-1 infection”,II Farmaco, vol. 54, pp. 26-45, 1999.

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