CXCR2 inhibitors

Details CXCR2 inhibitors CXCR2 inhibitors

2011-04-05

2011-04-05

Havlin, Robert (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C514S367000

Reexamination Certificate

active

07919628

ABSTRACT:
The invention relates to compounds of the formula I:in which R1, R2, X, A, B, D and Y1 to Y4 have the meanings indicated in the claims, and/or a pharmaceutically acceptable salt and/or a prodrug thereof. Because of their properties as inhibitors of chemokine receptors, especially as CXCR2 inhibitors, the compounds of the formula I and the pharmaceutically acceptable salts and prodrugs thereof are suitable for the prevention and treatment of chemokine mediated diseases.

REFERENCES:
patent: 2002/0123522 (2002-09-01), Fritz et al.
patent: WO99/07351 (1999-02-01), None
Kubinyi (3D QSAR in Drug Design: Ligand-Protein Interactions and Molecular Similarity, vol. 2-3, Springer, 1998, 800 pages); pp. 243-244 provided.
CAPLUS Abstract of: Jodlbauer et al. (J. Chromatography, A (2002), 945(1-2), 45-63).
Boschelli et al., Inhibition of E-Selectin-, ICAM-1-, and VCAM-1-Mediated Cell Adhesion by Benzo(b)thiophene-, Benzofuran-, Indole-, and Naphthalene-2-carboxamides: Identification of PD 144795 as a Antiinflammatory Agent, J. Med. Chem., vol. 38 (1995, pp. 4597-4614.

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