Cushioning beads and tablet comprising the same capable of formi

Details Cushioning beads and tablet comprising the same capable of formi Cushioning beads and tablet comprising the same capable of formi

1996-09-06

1998-07-14

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424489, 424480, A61K 920

Patent

active

057800553

ABSTRACT:
Cushioning beads comprising microcrystalline cellulose and a disintegrant (preferably croscarmellose sodium) are disclosed. The cushioning beads are prepared by extrusion-spheronization, followed by freeze-drying. Also disclosed, are water-dispersible tablets having high tensile strength, comprising the cushioning beads and biologically active ingredient-loaded beads, wherein optionally, the tablets can contain a viscosity enhancer in the form of separate beads, or as a component of the biologically active ingredient-loaded beads such that viscosity is rapidly generated when the tablets come in contact with water, and a homogenous suspension is formed, which can be easily swallowed by children and the elderly, with minimal effect of the biologically active ingredient release properties. The tablets are useful for sustained delivery of large doses of biologically active ingredients where swallowing of a large tablet or capsule poses a problem.

REFERENCES:
patent: 4886669 (1989-12-01), Ventquras et al.
patent: 5147655 (1992-09-01), Ibsen
patent: 5283065 (1994-02-01), Doyon et al.
patent: 5643591 (1997-07-01), Mehra et al.
Aulton et al, Drug Development and Industrial Pharmacy, 20(20):3069-3104 (1994).
Habib et al, "Synthesis and Evaluation of Carbopol Beads Produced by Dry Powder Layering", American Association of Pharmaceutical Scientists, Abstract and Poster (Nov. 1995).
Habib et al, "Synthesis and Evaluation of Beads Containing Partially Neutralized Carbopol Produced by Extrusion Spheronization", American Association of Pharmaceutical Scientists, Abstract and Poster (Nov. 1995).

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