Electricity: measuring and testing – Electrolyte properties – Using a conductivity determining device
Reexamination Certificate
2004-09-17
2008-08-05
Hirshfeld, Andrew H. (Department: 2858)
Electricity: measuring and testing
Electrolyte properties
Using a conductivity determining device
C324S439000, C205S778000
Reexamination Certificate
active
07408359
ABSTRACT:
The current measuring device includes an upper solution chamber (3) and a lower solution chamber (8) whose bottom has a support layer (5) and measures a current flowing via an artificial lipid bilayer membrane (2) formed on a small hole (4) of the upper solution chamber (3), wherein the lower solution chamber (8) is provided below the upper solution chamber (3) by being surrounded with a bottom plate (6) and an interval keeping member (7a). An internal pressure of the lower solution chamber (8) is dropped so that the artificial lipid bilayer membrane (2) formed on the small hole (4) swells to the side of the lower solution chamber (8) so as to be thinner, and the thinner artificial lipid bilayer membrane (2) is supported by the support layer.
REFERENCES:
patent: 6300108 (2001-10-01), Rubinsky et al.
patent: 7201836 (2007-04-01), Vogel et al.
“Stochastic Sensors Inspired By Biology”, H. Bayley & P.S. Cremer, Nature vol. 413, Sep. 13, 2001, 226-230, © 2001 Macmillian Magazines Ltd.
“Development of an Experimental Apparatus for Simultaneous Observation of Optical and Electrical Signals From Single Ion Channels”, T. Ide, Y. Takeuchi and T. Yanagida, Single Molecules.3 (2002) 1, p. 33-42, © Wiley-VCH Verlag Berlin GmbH.
Toru Ide et al., “An Artificial Lipid Bilayer Formed On An Agarose-Coated Glass for Simultaneous Electrical And Optical Measurement of Single Ion Channels”, Biochemical and Biophysical Research Communications vol. 265, No. 2, p. 595-599, © 1999.
A. G. Macdonald et al., “Combined Spectroscopic And Electrical Recording Techniques In Membrane Research: Prospects of Single Channel Studies”, Progress In Biophysics & Molecular Biology vol. 63, No. 1, p. 1-29, © 1995.
Harness & Dickey & Pierce P.L.C.
He Amy
Hirshfeld Andrew H.
Japan Science and Technology Agency
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