Curcumin (diferuloylmethane) inhibition of NF.kappa.B activation

Details Curcumin (diferuloylmethane) inhibition of NF.kappa.B activation Curcumin (diferuloylmethane) inhibition of NF.kappa.B activation

1996-09-26

1999-04-06

Criares, Theodore J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ketone doai

A61K 3112

Patent

active

058919244

ABSTRACT:
The present invention provides a method of inhibiting the activation of the NF.kappa.B transcription factor in an animal in need of such treatment comprising the step of administering to said animal a pharmacologically effective dose of curcumin. Also provided is a method of inhibiting the nuclear translocation of the p65 subunit of the NF.kappa.B transcription factor in a cell or in an animal in need of such treatment comprising the step of administering to said animal a pharmacologically effective dose of curcumin.

REFERENCES:
patent: 4959503 (1990-09-01), Connor et al.
patent: 5401504 (1995-03-01), Das et al.
patent: 5583242 (1996-12-01), Schieven

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