Curacin A analogs exhibiting antiproliferative activity against

Details Curacin A analogs exhibiting antiproliferative activity against Curacin A analogs exhibiting antiproliferative activity against

1998-07-14

2000-05-02

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548203, C07D27724, A61K 31427

Patent

active

060573481

ABSTRACT:
Isomers of a cytotoxic compound isolated and purified from a marine cyanobacterium Lyngbya majuscula are disclosed. The compound, termed "curacin D", exhibits substantial biological activity against proliferating cells. Analogs of curacin A also are described, as are formulations that include curacin D and the curacin A analogs. The curacins A-D and analogs of curacin A exhibit antimitotic behavior.

REFERENCES:
Verdier-Pinard Mol. Pharm. 53(1) 62 1998, Jan. 1998.
Nagle et al., "Absolute Configuration of Curacin A, a Novel Antimitotic Agent from the Tropical Marine Cyanobacterium Lyngbya majuscula," Tetrahedron Letters, vol. 36, No. 8, pp. 1189-1192 (1995).

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