Cultures of GFAP nestin cells that differentiate to neurons

Details Cultures of GFAP nestin cells that differentiate to neurons Cultures of GFAP nestin cells that differentiate to neurons

2007-12-04

2007-12-04

Davis, Ruth A (Department: 1651)

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

C435S366000, C435S368000, C435S378000

Reexamination Certificate

active

11062886

ABSTRACT:
Cultures of cells immunoreactive for glial fibrillary acidic protein (GFAP), as well as for the intermediate filament marker nestin were grown in a medium including epidermal growth factor (EGF) and serum. The cultured cells had the morphology of astroglial cells. The cells can be proliferated in adherent or suspension cultures. Depending on the culture conditions, the cells can be induced to differentiate to neurons or glial cells. The cultures can be expanded over a large number of passages during several months, and survive, express an astroglial phenotype and integrate well after transplantation into both neonatal and adult rat forebrain.

REFERENCES:
patent: 4352883 (1982-10-01), Lim
patent: 4353888 (1982-10-01), Sefton
patent: 4968733 (1990-11-01), Müller et al.
patent: 4976859 (1990-12-01), Wechs
patent: 5071741 (1991-12-01), Brockbank
patent: 5084350 (1992-01-01), Chang et al.
patent: 5158881 (1992-10-01), Aebischer et al.
patent: 5284761 (1994-02-01), Aebischer et al.
patent: 5338839 (1994-08-01), McKay et al.
patent: 5750376 (1998-05-01), Weiss et al.
patent: 5753506 (1998-05-01), Johe
patent: 5766948 (1998-06-01), Gage et al.
patent: 5800828 (1998-09-01), Dionne et al.
patent: 5851832 (1998-12-01), Weiss et al.
patent: 5968829 (1999-10-01), Carpenter
patent: 6040180 (2000-03-01), Johe
patent: 6258353 (2001-07-01), Isacson et al.
patent: 6294383 (2001-09-01), Isacson et al.
patent: 6497872 (2002-12-01), Weiss et al.
patent: 2002/0151066 (2002-10-01), Rubenstein et al.
patent: 2003/0032181 (2003-02-01), Weiss et al.
patent: WO 92/04033 (1992-03-01), None
patent: WO 92/19195 (1992-11-01), None
patent: WO 93/14191 (1993-07-01), None
patent: WO 95/05452 (1995-02-01), None
patent: WO 95/07611 (1995-03-01), None
patent: WO 96/04368 (1996-02-01), None
patent: WO 96/09543 (1996-03-01), None
patent: WO 96/27287 (1996-07-01), None
patent: WO 96/29862 (1996-10-01), None
patent: WO 98/14058 (1998-04-01), None
patent: WO 98/30678 (1998-07-01), None
patent: WO 00/24897 (2000-05-01), None
David et al.J. Biol. Chem., 271(16):9185-9188 (1996).
Parmar et al.Mol. Cell. Neurosci., 21:645-656 (2002).
Skogh et al.Neurosci., 120:379-385 (2003).
Stenman et al.J. Neurosci., 23(1):167-174 (2003).
BjörklundTrends Neurosci., 14(8):319-322 (1991).
Brüstle et al.Neuron,15:1275-1285 (1995).
Cunningham et al.J. Neurosci. Meth., 47:105-114 (1993).
Daadi et al.J. Neurosci., 19(11):4484-4497 (1999).
Doetsch et al.Cell, 97(6):703-716 (1999).
Duncan et al.J. Neurocytol., 17:351-360 (1988).
Eriksson et al. Eur. J. Neurol., 12(Supp. 11):263 (2000).
Eriksson et al.Exp. Neurol., 164:184-199 (2000).
Faaland et al.Mol. Cell. Biol., 11(5):2697-2703 (1991).
Fagerström et al.Eur. J. Neurol., 12(Supp. 11):326 (2000).
Fields et al.J. Neuroimmunol., 8:311-330 (1985).
Gallo et al.J. Neurosci., 15(1):394-406 (1995).
Gates et al.Neurosci., 84(4):1013-1023 (1998).
GruberTransplantation, 54(1):1-11 (1992).
Hammang et al.Exp. Neurol., 147:84-95 (1997).
Hankin et al.J. Comp. Neurol., 263:455-466 (1987).
Hulspas et al.Experimental Neurol., 148(1):147-156 (1997).
Hunter-SchaedleJ. Neurobiol., 33:459-472 (1997).
Jessen et al.J. Neurocytol., 13:923-934 (1984).
Johansson et al.Cell, 96(1):25-34 (1999).
Kalyani et al.J. Neurosci., 18(19):7856-7868 (1998).
Karlsson et al.Biophys. J., 65:2524-2536 (1993).
Lagenaur et al.J. Supramol. Struct. Cell. Biochem., 15:335-346 (1981).
Lagenaur et al.J. Neurobiol., 23:71-88 (1992).
Lendahl et al.Cell, 60:585-595 (1990).
Lin et al.Neurobiol. Dis., 2:79-85 (1995).
Lin, et al.Hum. Gene Ther., 8:331-339 (1997).
Lundberg et al.Exp. Neurol., 139:39-53 (1996).
Mi et al.Dev. Brain Res., 106:145-154 (1998).
Misson et al.Dev. Brain Res., 44:95-108 (1988).
MiyaguchiJ. Struci. Biol., 120(1):61-68 (1997).
Olsson et al.Neurosci., 79(1):57-78 (1997).
Palmer et al.Mol. Cell. Neurosci., 8:389-404 (1997).
Reynolds et al.Dev. Biol., 175:1-13 (1996).
Reynolds et al.Science, 255:1707-1710 (1992).
Reynolds et al.J. Neurosci., 12(11):4565-4574 (1992).
Ridet et al.Hum. Gene Ther., 10:271-280 (1999).
Rutka et al.Int. J. Dev. Neurosci., 17(5-6):503-515 (1999).
Santa-Olalla et al.J. Neurosci. Res., 42(2):172-183 (1995).
Schinstine et al.Edperimental Neurol., 141(1):67-78 (1996).
Svendsen et al.Exp. Neurol., 148:135-146 (1997).
Tornatore et al.Cell Transplant., 5(2):145-163 (1996).
Vescovi et al.Exp. Neurol., 156:71-83 (1999).
Weiss et al.J. Neurosci., 16(23):7599-7609 (1996).
Weiss et al.Trends Neurosci., 19:387-393 (1996).
Wictorin et al.Eur. J. Neurosci., 3:86-101 (1991).
Yong et al.Proc. Nat. Acad. Sci. USA, 88:7016-7020 (1991).
Zheng et al.Proc. Natl. Acad. Sci. USA, 88:8067-8071 (1991).
Zhou et al.J. Comp. Neurol., 317:145-155 (1992).

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