Cultured, full-thickness integument substitutes based on three-d

Details Cultured, full-thickness integument substitutes based on three-d Cultured, full-thickness integument substitutes based on three-d

1995-10-12

1997-09-09

Webman, Edward J.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Matrices

424486, 424488, 424DIG7, 424400, 623 15, A61F 210

Patent

active

056653913

ABSTRACT:
A cultured, full-thickness integument substitute is disclosed which can be implanted in a patient suffering from severe burns, for example; and consists of a three-dimensional matrix membrane with essentially two surfaces because the length and width are substantially greater than the thickness; the membrane has pores in the area of a first surface thereof which are directly connected to but substantially larger on average than those in the area of the opposite surface of the membrane, and those pores have immobilized within them cells and components of the dermal layer of the integument; the membrane has pores in the area of a second surface thereof which are directly connected to but substantially smaller on average than those in the area of the opposite surface of the membrane, and those pores have immobilized within them cells and components of the epidermal layer of the integument; the membrane also has a lateral pore structure in its internal space which interconnects those pores which pass from one surface to the other of the membrane, permitting co-planar flow of a liquid or suspension through the membrane.

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