Culture of goblet cells

Details Culture of goblet cells Culture of goblet cells

2008-01-08

2008-01-08

Davis, Ruth A (Department: 1651)

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Primate cell, per se

C435S325000, C435S371000, C424S093700, C424S571000, C424S572000, C424S574000

Reexamination Certificate

active

07316927

ABSTRACT:
The invention encompasses isolation, culture and characterization of goblet cells in vitro from mammalian conjuctiva. Goblet cells can be cultured from conjunctiva of such mammals as, e.g., humans, rats, mice, rabbits and the like. In another aspect of the invention, the culture of goblet cells has a concentration of pure goblet cells of 10% or greater. In a further embodiment, the invention comprises an immortalized goblet cell line.

REFERENCES:
patent: 5872215 (1999-02-01), Osbourne et al.
Lancaster et al., “Goblet cell carcinoid arising in a mature teratoma of the mediastinum”, Am J Surg Pathology, Jan. 1997, 21(1):109-13, abstract.
Shrestha et al., “Immunohistochemical, ultrastructural and molecular study of well differentiated adenocarcinomas of the lung predominantly composed of goblet cells”, Lung Cancer, Nov. 1998, 22(2):103-17, abstract.
Hughes et al., “Gastric mucous neck cell and intestinal goblet cell phenotypes in gastric adenocarcinoma”, J Clim Pathology, 1997, 50:741-748.

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