Cultivating streptomyces to produce an esterase inhibitor

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing heterocyclic carbon compound having only o – n – s,...

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435899, C12P 1702

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active

042424534

ABSTRACT:
A new physiologically active substance named esterastin is now provided, which inhibits the activity of esterase and is useful as an immunosuppressive drug. Esterastin is produced by cultivating a micro-organism Streptomyces MD4-C1 identified as FERM-P 3723 or ATCC. 31336 in a culture medium under aerobic conditions and recovering it from the resulting culture. Esterastin is the compound having the formula ##STR1##

REFERENCES:
patent: 3629404 (1971-12-01), Florent et al.
patent: 3840516 (1974-10-01), Umezawa et al.

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