CTP extended form of glycoprotein hormones

Details CTP extended form of glycoprotein hormones CTP extended form of glycoprotein hormones

1994-05-06

1996-12-17

Walsh, Stephen G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530396, 530397, 530398, 530399, 435 694, C07K 1459, A61K 3824

Patent

active

055853455

ABSTRACT:
Extended forms of beta subunits of human glycoproteins wherein the amino acid sequence of a carboxy terminal peptide (CTP) representing positions from about 112-118 to 145 of the human CG-beta subunit or a variant form thereof is appended to the C-terminus are disclosed. Recombinant materials for the production of these extended human glycoprotein beta subunits and production of the modified hormones containing the extended beta subunits are also described. Pharmaceutical compositions containing the modified forms of these hormones are useful in pharmacological applications analogous to those of the unmodified forms.

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