Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1995-06-07
1999-11-02
Feisee, Lila
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
53038815, 53038873, 530866, 530868, 530861, 4241411, 4241431, 435331, 435334, C07K 1600
Patent
active
059773189
ABSTRACT:
The invention identifies the CTLA4 receptor as a ligand for the B7 antigen. The complete amino acid sequence encoding human CTLA4 receptor gene is provided. Methods are provided for expressing CTLA4 as an immunoglobulin fusion protein, for preparing hybrid CTLA4 fusion proteins, and for using the soluble fusion proteins, fragments and derivatives thereof, including monoclonal antibodies reactive with B7 and CTLA4, to regulate T cell interactions and immune responses mediated by such interactions.
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Brady William
Damle Nitin K.
Kiener Peter A.
Ledbetter Jeffrey A.
Linsley Peter S.
Bristol Myers Squibb Company
Feisee Lila
Lazar-Wesley Eliane
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